Yi Jin, Steven G. Potkin, Aaron S. Kemp, Steven T.Huerta, Gustavo Alva, Trung Minh Thai, Danilo Carreon, and William E. Bunney, Jr.
Therapeutic Effects of Individualized Alpha Frequency Transcranial Magnetic Stimulation (TMS) on the Negative Symptoms of Schizophrenia
Schizophr Bull, Advance Access published on October 27, 2005

ABSTRACT
Previous research has demonstrated that reduction of alpha-frequency EEG (8-13 Hz) may have particular relevance to schizophrenia symptomatology. Repetitive Transcranial Magnetic Stimulation (rTMS) was utilized to investigate this relationship and assess its efficacy as a treatment. Twenty-seven patients received two weeks of daily treatment with either EEG-guided alpha, 3Hz, 20Hz, or sham stimulation bilaterally over the dorsolateral prefrontal cortex. EEG-guided rTMS demonstrated a superior therapeutic effect (29.6% reduction in negative symptoms) to the other three conditions (< 9%), which was highly correlated with increases (34%) in frontal alpha power.
These results affirm that the resonant features of alpha-frequency EEG play an important role in the pathophysiology of schizophrenia, and merit further investigation as a particularly efficacious frequency for rTMS treatments.

Trung Minh Thai, M.D.
Associate Clinical Professor
Department of Psychiatry
UCI Medical Center
714 456 3790

YDNN Tồn Trữ Tài Liệu Khảo Cứu Y Dược Khoa Của Người Việt