Contributions of lean mass and fat mass to bone mineral density: A study in postmenopausal women
Ho-Pham LT, Nguyen ND, Lai TQ, Nguyen TV

BMC Musculoskelet Disord. 2010 Mar 26;11(1):59.

ABSTRACT: BACKGROUND:
The relative contribution of lean and fat to the determination of bone mineral density (BMD) in postmenopausal women is a contentious issue. The present study was undertaken to test the hypothesis that lean mass is a better determinant of BMD than fat mass.
METHODS: This cross-sectional study involved 210 postmenopausal women of Vietnamese background, aged between 50 and 85 years, who were randomly sampled from various districts in Ho Chi Minh City (Vietnam). Whole body scans, femoral neck, and lumbar spine BMD were measured by DXA (QDR 4500, Hologic Inc., Waltham, MA). Lean mass (LM) and fat mass (FM) were derived from the whole body scan. Furthermore, lean mass index (LMi) and fat mass index (FMi) were calculated as ratio of LM or FM to body height in metre squared (m2).
RESULTS: In multiple linear regression analysis, both LM and FM were independent and significant predictors of BMD at the spine and femoral neck. Age, lean mass and fat mass collectively explained 33% variance of lumbar spine and 38% variance of femoral neck BMD. Replacing LM and FM by LMi and LMi did not alter the result. In both analyses, the influence of LM or LMi was greater than FM and FMi. Simulation analysis suggested that a study with 1000 individuals has a 78% chances of finding the significant effects of both LM and FM, and a 22% chances of finding LM alone significant, and zero chance of finding the effect of fat mass alone.
CONCLUSIONS: These data suggest that both lean mass and fat mass are important determinants of BMD. For a given body size -- measured either by lean mass or height --women with greater fat mass have greater BMD.

YDNN: Bài này do Gs Nguyễn văn Tuấn và các cộng sự viên tường trình một trường hợp lâm sàng là một phụ nữ người Việt, hậu mãn kinh. Các tác giả muốn tìm hiểu vai trò của trọng khối thịt và trọng khối mỡ liên hệ mật độ xương (BMD, Bone mineral density).
Kết quả gợi ý cả 2 trọng khối thịt và mỡ đều quan trọng trong việc xác định mật độ xương.
Đối với phụ nữ đồng đều kích thước cơ thể, khi đo bằng trọng khối thịt hay chiều cao, nếu có trọng khối mỡ cao hơn sẽ có mật độ xương lớn hơn.
Bài này đăng trong báo BMC Musculoskelet Disord, 26: 59, 2010.

Xin cảm ơn Gs Tuấn đã gửi Abstract cho YDNN để được phép phổ biến.

TAGS: Trọng khối thịt (Lean mass), Trọng khối mỡ (Fat mass), Mật độ xương (Bone mineral density), Ho-Pham LT, Nguyen ND, Lai TQ, Nguyen VT

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