1)
Role of Vascular Endothelial Growth Factor in Prostate Cancer
2) Cellular Signaling Pathways and Pathophysiology of Pulmonary Arterial
Hypertension
Professor Đinh-Xuân Anh-Tuấn
và các đồng nghiệp
1) Urology. 2006 Aug ;68:244-8 [Pubmed] [Scholar] [Select]
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Role of vascular endothelial
growth factor in prostate cancer.
Nicolas Barry Delongchamps, Michaël Peyromaure,
Anh Tuan Dinh-Xuan
2) Duong-Quy S (S) papers: 1
Rev Mal Respir. 2006 Feb ;23:3S75-83 [Pubmed] [Scholar] [Select] [Drop]
[Hide] [Show] Cellular signalling
pathways and pathophysiology of pulmonary arterial hypertension
P Dao, D Montani, S Duong-Quy, A
T Dinh-Xuan
INTRODUCTION:
Pulmonary arterial hypertension (PAH) is a disease of complex aetiology
involving in varying degrees both genetic and environmental factors.
BACKGROUND:
Thanks to progress in biology over the past 15 years the physiological
consequences of cellular and molecular abnormalities are much better understood.
Recent work has allowed better understanding of the different cellular
signalling pathways controlling pulmonary vascular tone and cell growth.
It appears that these pathways form a dense and complex network involving
several groups of molecules of which NO, cGMP, ET-1 and its receptors,
are at the most important.
VIEWPOINT:
The pathophysiology of PAH may be regarded as a disorder of cellular signaling
where molecular abnormalities disturb the balance between the different
factors controlling vascular tone and cell proliferation.
CONCLUSIONS: PAH may be viewed as a disease of cellular signalling where
the molecular abnormalities not only affect a single signalling pathway
but involve multiple cross-talks between groups of molecules controlling
vascular smooth muscle tone and cell growth and differentiation.
Government Information BioInfoBank Library, 2006-12-03
