Ts
Nguyễn Văn Tuấn và nghiên cứu: http://www.biomedcentral.com/1471-2350/7/57/abstract
Beta3-Adrenergic receptor
gene, body mass index, bone mineral density and fracture risk in elderly
men and women:
the Dubbo Osteoporosis Epidemiology Study (DOES)
Claire
Y Wang 
, Nguyen D Nguyen
, Nigel A Morrison
, John A Eisman
, Jacqueline
R Center and Tuan V Nguyen
BMC Medical Genetics 2006, 7:57 doi:10.1186/1471-2350-7-57
| Published |
|
5 July 2006 |
Abstract (provisional)
Background
Recent studies have suggested that the Arg allele of beta3-adrenergic receptor (ADRB3) gene is associated with body mass index (BMI), which is an important predictor of bone mineral density (BMD) and fracture risk. However, whether the ADRB3 gene polymorphism is associated with fracture risk has not been investigated. The aim of study was to examine the inter-relationships between ADRB3 gene polymorphisms, BMI, BMD and fracture risk in elderly Caucasians.
Methods
Genotypes of the ADRB3 gene were determined in 265 men and 446 women aged 60+ in 1989 at entry into the study, whose BMD were measured by DXA (GE Lunar, WI USA) at baseline. During the follow-up period (between 1989 and 2004), fractures were ascertained by reviewing radiography reports and personal interviews.
Results
The allelic frequencies of the Trp and the Arg alleles were 0.925 and 0.075 respectively, and the relative frequencies of genotypes Trp/Trp, Trp/Arg and Arg/Arg 0.857, 0.138 and 0.006 respectively. There was no significant association between BMI and ADRB3 genotypes (p=0.10 in women and p=0.68 in men). There was also no significant association between ADRB3 genotypes and lumbar spine or femoral neck BMD in either men and women. Furthermore, there were no significant associations between ADRB3 genotypes and fracture risk in both women and men, either before or after adjusting for and, BMD and BMI.
Conclusions
The present data suggested that in Caucasian population the contribution of ADRB3 genotypes to the prediction of BMI, BMD and fracture risk is limited.
Ts Nguyễn Ðức Thái bàn luận bài nghiên cứu của
Ts Nguyễn Văn Tuấn:
Thân gửi Anh Tuấn:
Chúc mừng công trình nghiên cứu của anh về Adrenergic receptor gene và
bone disease.
Tuy là kết quả âm tính, nhưng theo kinh nghiệm của tôi về gene glaucoma
thì bài báo cáo của anh rất quan trọng. Rất nhiều nhóm nghiên cứu kể cả
chúng tôi đã phải chứng minh một số candidate genes KHÔNG liên hệ bệnh
glaucoma và từ đó mới xác định được hướng đi và thu hẹp khoảng cách để
tìm ra gene đầu tiên, TIGR, cho glaucoma.
Cầu chúc anh thêm nhiều bài báo và thành công.
Thân,
THÁI
(YDNN: Tồn Trữ Tài Liệu Y Dược Khoa Của Người Việt)
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