Reduced
exhaled NO is related to impaired nasal potential difference in patients
with cystic fibrosis.
Bác Sĩ Ðinh-Xuân Anh-Tuấn
và các Ðồng Nghiệp
Vascul Pharmacol. 2005 Dec; 43:385-9
16182611
J Texereau , I Fajac , D Hubert , J
Coste , D J Dusser , T Bienvenu , J Dall'Ava-Santucci , A T Dinh-Xuan
Nitric oxide (NO)
plays a central role in many airway physiological functions, and its production
appears to be related with progression of lung disease in patients with
cystic fibrosis (CF). However, underlying mechanisms which specifically
link NO and CF-related lung disease remain unclear.
Following in vitro and animal studies suggesting a role for NO in ion
transport in various epithelia, this work investigates the relationship
between transepithelial baseline potential difference (BPD), an index
of airway ion transport, and exhaled NO in the airways of adult patients
with CF. Association with other phenotypic traits, lung function tests
and CFTR genotype was also assessed. Using simple linear regression, F(E)NO
and transepithelial BPD values were significantly inversely correlated
(p<0.001, r=-0.53). Polynomial analysis evidenced an asymptotic relationship
between F(E)NO and BPD values, yielding a plateau for absolute BPD values
above 50 mV. This relation was not altered by adjustment for clinical
and genetic characteristics of the patients.
The relationship between exhaled NO and transepithelial BPD suggests that
low NO concentrations likely worsens airway ion transport impairment resulting
from CFTR defect. These results fit with experimental studies that suggest
the inhibitory effect of NO on sodium absorption, which is the main determinant
of airway basal transepithelial conductance.
Mesh-terms: Adult; Cystic Fibrosis Transmembrane Conductance Regulator, genetics; Cystic Fibrosis, metabolism; Cystic Fibrosis, physiopathology; Female; Genotype; Humans; Linear Models; Male; Membrane Potentials, physiology; Middle Aged; Nasal Mucosa, physiopathology; Nitric Oxide, metabolism; Research Support, Non-U.S. Gov't; Respiratory Function Tests;
